| 摘要 |
A method for enhancing or restoring lacrimal function by the topical administration of a cyclosporin in a pharmaceutically acceptable excipient. Lacrimal function is enhanced or restored in patients suffering from abnormalities of the tear film including an absolute or partial deficiency in aqueous tear production, called keratoconjunctivitis sicca or KCS, regardless of etiology, including autoimmune dysfunction of the lacrimal glands. The treatment is also useful in the enhancement or restoration of normal tear production, and normal healing of the surface of the eye. The preferred composition for topical administration to the eye consists of cyclosporin dissolved in corn oil. The composition may further include antioxidants, lubricants, antibiotics, antifungals, antivirals, pilocarpine, vasoconstrictors, surfactants, wetting agents, anti-inflammatory agents (i.e. corticosteroids), preservatives, mucolytic agents (i.e. bromhexine, acetylcysteine), as well as other compounds. The most preferred composition is 2% cyclosporin, 1 mole % alpha tocopherol and 0.005% methyl paraben in corn oil.
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