发明名称 |
Cyclopropenone derivatives |
摘要 |
A novel cyclopropenone derivative (I) which possesses a potent inhibitory activity against thiol protease such as papain, cathepsin B, cathepsin H, cathepsin L, calpain or the like with excellent properties regarding oral absorbance, tissue transference and cell membrane permeability, and are clinically useful in the treatment of various diseases such as muscular dystrophy, amyotrophy. Also provided are a process for producing the compound (I) and a pharmaceutical composition containing the same.
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申请公布号 |
US5416117(A) |
申请公布日期 |
1995.05.16 |
申请号 |
US19940202555 |
申请日期 |
1994.02.28 |
申请人 |
MITSUBISHI KASEI CORPORATION |
发明人 |
ANDO, RYOICHI;MORINAKA, YASUHIRO;TAKAHASHI, CHIZUKO;TAMAO, YOSHIKUNI;TOBE, AKIHIRO |
分类号 |
A61K31/165;A61K31/18;A61K31/19;A61K31/195;A61K31/27;A61K31/415;A61K31/47;A61K38/00;A61P1/16;A61P3/00;A61P5/00;A61P7/02;A61P9/00;A61P9/10;A61P19/10;A61P25/00;A61P25/02;A61P25/28;A61P29/00;A61P35/00;A61P37/08;A61P43/00;C07C237/06;C07C237/08;C07C237/20;C07C237/22;C07C271/18;C07C271/22;C07C271/24;C07C271/34;C07C271/54;C07C275/16;C07C275/24;C07C275/28;C07C275/30;C07C311/03;C07C311/06;C07C311/14;C07C311/16;C07C311/19;C07C311/29;C07C317/24;C07C317/44;C07C323/49;C07C323/60;C07C333/04;C07D211/62;C07D211/64;C07D213/30;C07D213/34;C07D213/55;C07D213/81;C07D213/82;C07D215/36;C07D215/48;C07D215/54;C07D231/14;C07D233/90;C07D239/28;C07D307/68;C07D333/38;C07K5/06;C07K5/065;C07K14/81;(IPC1-7):A61K31/165;C07C311/18 |
主分类号 |
A61K31/165 |
代理机构 |
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