| 摘要 |
In accordance with the present invention, a composition and method is provided for preserving organs and tissue for transplantation. More particularly, the present invention relates to a method for preserving organs and tissues by perfusing the organ or tissue with a perfusion medium containing an effective amount of a polyoxypropylene/polyoxyethylene surface-active copolymer. The surface-active copolymer may be an ethylene oxide-propylene oxide condensation product with the following general formula (I): HO(C2H4O)b(C3H6O)a(C2H4O)bH, wherein a is an integer such that the hydrophobe represented by (C3H6O) has molecular weight of approximately 950 to 4000 daltons, preferably approximately 1200 to 3500 daltons, and b is an integer such that the hydrophile portion represented by (C2H4O) constitutes approximately 50 % to 90 % by weight of the compound.
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