| 摘要 |
<p>A novel 5-0-pyrimidyl-2,3-dideoxy-1-thio-D-furanoside derivative represented by general formula (I) or an L-isomer thereof, wherein X represents hydrogen, fluorine or azide group; R1 represents C¿1?-C4 alkyl; R?2¿ represents hydrogen, methyl, fluorine or trifluoromethyl; and R3 represents either C¿1?-C10 alkyl, or C6-C15 aryl which may be substituted by at least one substituent selected from the group consisting of chlorine, bromine, methyl, ethyl and nitro. By conducting intramolecular N-glycosylation between the above compound and a sulfonium ion generating reagent, a β-2',3'-dideoxynucleoside derivative useful as a precursor for antiviral agents such as AZT, DDC and FLT can be produced in a high yield with an extremely high selectivity for β-isomer while forming no or little corresponding β-isomer.</p> |
