PHENYLINDOLE COMPOUNDS

摘要

Phenylindole compound having general formula (I), wherein R1-R4 are independently hydrogen, deuterium, halogen, alkyl, aryl, hydroxy, alkoxy, aryloxy, alkylthio and arylthio; or R1 and R2 and/or R3 and R4 constitute an oxo or thioxo group; or R1 and R2 and/or R3 and R4, respectively, are joined together to form a 3-8 membered spiro ring; are non-cataleptogenic 5-HT2 receptor antagonists in vivo and show in a model indicative of antipsychotic effect. Thus the compounds may be useful in the treatment of psychosis, depression, negative symptoms of schizophrenia, hypertension or extrapyramidal side effects induced by antipsychotic drugs.