发明名称 |
MA having a hydroxylated or oxidised lipid side chain and moenomycin analogues, and a process for the preparation and the use of these compounds |
摘要 |
The invention relates to MA of the formula I <IMAGE> in which R<1>, R<2>, R<4> and R<5> independently of one another are a hydroxyl group or hydrogen and R<3> is hydrogen, the bond between the C atom carrying the substituent R<4> and the C atom carrying the substituent R<5> being a single bond, or R<1> and R<2> independently of one another are a hydroxyl group or hydrogen and R<3> is hydrogen, the bond between the C atom carrying the substituent R<4> and the C atom carrying the substituent R<5> being a double bond or R<1>, R<2> and R<5> independently of one another are a hydroxyl group or hydrogen and R<3> and R<4> together are an oxo group. MA is hydroxylated or oxidised in the lipid side chain by microorganisms of the genus Cryptococcus and in this form is a starting compound for the preparation of moenomycin analogues which can be employed as medicaments. The moenomycin analogues have the following chemical structure: <IMAGE> in which R<1> to R<5> have the abovementioned meanings.A
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申请公布号 |
DE4337630(A1) |
申请公布日期 |
1995.05.11 |
申请号 |
DE19934337630 |
申请日期 |
1993.11.04 |
申请人 |
HOECHST AG, 65929 FRANKFURT, DE |
发明人 |
ARETZ, WERNER, DR., 61462 KOENIGSTEIN, DE;HEDTMANN, UDO, DR., 60433 FRANKFURT, DE |
分类号 |
C07C59/60;C07H3/06;C07H13/12;C12P7/42;(IPC1-7):C07C59/60;C07C59/76;C07C51/42;C12N1/16;A61K31/71 |
主分类号 |
C07C59/60 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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