3/2 HYDRATE AND ANHYDRATE 7-£(7-(S)-AMINO-5-AZASPIRO £2.4|- -HEPTANE-5-YL|-8-CHLORINE-6-FLUORO-1-£(1R,2S)-2- -FLUOROCYCLOPROPYL-4-OXO-1,4-DIHYDROQUINOLINE -3- CARBOXYLIC ACID, METHOD OF SELECTIVE PRODUCTION OF 3/2 HYDRATE, ITS CRYSTALS AND ANTIBACTERIAL AGENTS ON ITS BASE

摘要

Preparation method for crystalline form of 3/2 hydrate 7-[(7-(S)-amino-5-azaspiro[2.4]heptane-5-yl]-8-chloro-6-fluoro- 1-[(1R,2S)-2-fluorocyclopropyl]-4-oxo-1,4-dihydroquinoline-3- carboxylic acid, in which the hydrate 7-[(7-(S)-amino-5- azaspiro[2.4]heptane-5-yl]-8-chloro-6-fluoro-1-[(1R,2S)-2- fluorocyclopropyl]-4-oxo-1,4-dihydroquinoline-3-carboxylic acid is recrystallised from the aqueous solvent, whilst the contents of water in this aqueous solvent is in the range from 5 to 100 wt. %, preferably from 50 to 75 wt. %. As an aqueous solvent ethanol containing ammonia can be preferably used.