Methods for inhibiting cartilage degradation.

摘要

A method of inhibiting cartilage degradation comprising administering to a human or other mammal in need of treatment an effective amount of a compound having the formula wherein R<1> and R<3> are independently hydrogen, -CH3, or wherein Ar is optionally substituted phenyl; R<2> is selected from the group consisting of pyrrolidino and piperidino, a pharmaceutically acceptable salt or solvate thereof.