Biologically active bactericidal/permeability-increasing protein fragments.

摘要

A biologically active polypeptide fragment of mammalian bactericidal/permeability increasing proteins is provided. Also provided are methods for isolating the fragments and methods for employing the polypeptide fragments as antimicrobial agents active against susceptible gram-negative bacteria. Also provided is a purified, isolated DNA sequence encoding human bactericidal/permeability-increasing protein and biologically-active fragments thereof.