Process for selecting an enantiomer of a hydroxy lactone using pseudomonas lipase

摘要

An enantiomerically pure compound of the formula is prepared when the associated racemic mixture is reacted with an acrylating agent R3-C(O)-O-R in the presence of a microorganism or enzyme derived therefrom capable of catalyzing transesterification of an alcohol. X1 and X2 are each independently halogen, R is alkyl, R1 and R2 are each independently alkyl, cycloalkyl, aralkyl or aryl and R3 is alkyl, cycloalkyl, aryl or aralkyl.