发明名称 |
Yeast assay to identify inhibitors of dibasic amino acid processing endoproteases |
摘要 |
The present invention relates to a novel method to identify compounds that inhibit proteolytic cleavage by dibasic amino acid processing endoproteases that includes contacting a yeast strain with a putative inhibitory compound under conditions in which, in the absence of the compound, the yeast strain can cleave a precursor protein having a dibasic amino acid processing site and determining if the putative inhibitory compound inhibits cleavage of the precursor protein. The present invention includes a method to identify compounds capable of inhibiting infectious agents, such as viruses, that depend upon dibasic amino acid processing endoprotease cleavage for propagation. The present invention also includes assay kits based on such a method.
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申请公布号 |
US5413914(A) |
申请公布日期 |
1995.05.09 |
申请号 |
US19930088322 |
申请日期 |
1993.07.07 |
申请人 |
THE REGENTS OF THE UNIVERSITY OF COLORADO |
发明人 |
FRANZUSOFF, ALEX |
分类号 |
A61K36/064;A61K38/00;A61K39/39;A61K47/48;A61K48/00;C07K14/16;C12N1/19;C12N9/00;C12N9/60;C12N9/64;C12N15/00;C12N15/113;C12N15/81;C12N15/82;C12Q1/00;C12Q1/02;C12Q1/37;(IPC1-7):C12Q1/37 |
主分类号 |
A61K36/064 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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