PROCESS FOR THE PREPARATION OF RUFLOXACIN AND SALTS THEREOF

摘要

Rufloxacin is prepared by reducing a quinolon disulfide of formula (II) subjecting the 2-mercaptoethyl quinolone thus obtained of formula (III) to a cyclization in a basic medium and hydrolyzing the rufloxacin ester thus obtained to isolate rufloxacin. A new method for hydrolyzing rufloxacin ester to rufloxacin and its pharmaceutically acceptable salts is also described.