发明名称 PROCESS FOR PREPARING 3,4-DIARYL-5-ISOXAZOLYL ACETIC ACID DERIVATIVES
摘要 A new process is disclosed for preparing 3,4-diaryl-5-isoxazolyl acetic acid derivatives having the general formula (I) or a pharmaceutically acceptable salt thereof. In the formula (I), R<1>, R<2>, R<3> and R<4> are the same or different and stand for hydrogen, lower alkyl, lower alkoxy, halogen or trifluoromethyl, Ar<1> and Ar<2> are the same or different and stand for phenyl or naphthyl substituted by R<1> and R<2> or by R<3> and R<4>. According to this process, appropriately substituted desoxybenzoinoximes are reacted with a carboxyl group-protected 3,3-dialkoxyacrylic acid derivative and the carboxyl protecting group is then removed. A compound having the above-mentioned general formula (I) is thus obtained that if required may be converted into a pharmaceutically acceptable salt.
申请公布号 WO9511888(A1) 申请公布日期 1995.05.04
申请号 WO1994AT00160 申请日期 1994.10.28
申请人 F. JOH. KWIZDA GESELLSCHAFT M.B.H.;TAIHO PHARMACEUTICAL CO., LTD.;EICHINGER, KARL 发明人 EICHINGER, KARL
分类号 C07D261/08 主分类号 C07D261/08
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