发明名称 |
Selective adenoviral mediated gene transfer into vascular neointima |
摘要 |
The present invention provides a method of selectively expressing DNA in neointimal cells in an injured blood vessel of a subject comprising administering a replication-deficient recombinant adenovirus which functionally encodes the DNA to the blood vessel at the site of injury, such that the adenovirus remains at the site of injury for a time sufficient for the adenovirus to selectively infect neointimal cells and thereby selectively express the DNA in neointimal cells. In particular, the invention provides administering a replication-deficient recombinant adenovirus which functionally encodes a DNA encoding a protein or an antisense ribonucleic acid. This method can be used to treat restenosis and, relatedly, prevent neointimal cell proliferation. |
申请公布号 |
AU8017394(A) |
申请公布日期 |
1995.05.04 |
申请号 |
AU19940080173 |
申请日期 |
1994.10.13 |
申请人 |
THE GOVERNMENT OF THE UNITED STATES OF AMERICA, AS REPRESENTED |
发明人 |
TOREN FINKEL;STEPHEN E EPSTEIN;RONALD G. CRYSTAL;RAUL J GUZMAN |
分类号 |
A61K38/45;A61K48/00;C12N15/861 |
主分类号 |
A61K38/45 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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