OXIDOREDUCTASE FROM FILAMENTOUS FUNGI, DNA CODING THEREFOR AND CELLS TRANSFORMED WITH SAID DNA

摘要

PCT No. PCT/NL94/00135 Sec. 371 Date Nov. 28, 1995 Sec. 102(e) Date Nov. 28, 1995 PCT Filed Jun. 10, 1994 PCT Pub. No. WO94/29453 PCT Pub. Date Dec. 22, 1994Disclosed is a new gene which codes for a NADPH cytochrome P450 oxidoreductase from filamentous fungi. Also disclosed are a recombinant DNA molecule which comprises at least a part of that gene, an RNA molecule derived therefrom and a new polypeptide (or protein), as well as at least one host cell transformed with such recombinant DNA molecule. Particularly suitable host cells are those originating from a filamentous fungus. With the polypeptides (proteins) and the host cells according to the invention, new processes for enzymatic conversions can be performed. In particular, enzymatic conversions by means of monooxygenases, more particularly by means of enzymes from the cytochrome P450 superfamily are improved with the invention.