发明名称 NOVEL (R)-5-CARBAMOYL-8-FLUORO-3-N,N-DISUBSTITUTED-AMINO-3,4-DIHYDRO-2H-1-BENZOPYRANES
摘要 Compounds of general formula (I), wherein R1 is n-propyl or cyclobutyl; R2 is isopropyl, tertiary butyl, cyclobutyl, cyclopentyl or cyclohexyl; R3 is hydrogen; R4 is hydrogen or methyl; as (R)-enantiomer and in the form of free base or pharmaceutically acceptable salts thereof, process for their preparation, pharmaceutical composition, use of and method of treatment of disorders in CNS.
申请公布号 WO9511891(A1) 申请公布日期 1995.05.04
申请号 WO1994SE01010 申请日期 1994.10.26
申请人 ASTRA AKTIEBOLAG;EVENDEN, JOHN, LESLIE;HAMMARBERG, EVA, MARIA;HANSSON, HANS, SVERKER;HELLBERG, SVEN, ERIK;JOHANSSON, LARS, GEORGE;LUNDKVIST, JOHAN, RUNE, MICHAEL;ROSS, SVANTE, BERTIL;SOHN, DANIEL, DUNGAN;THORBERG, SETH, OLOV 发明人 EVENDEN, JOHN, LESLIE;HAMMARBERG, EVA, MARIA;HANSSON, HANS, SVERKER;HELLBERG, SVEN, ERIK;JOHANSSON, LARS, GEORGE;LUNDKVIST, JOHAN, RUNE, MICHAEL;ROSS, SVANTE, BERTIL;SOHN, DANIEL, DUNGAN;THORBERG, SETH, OLOV
分类号 C07D311/58;A61K31/35;A61K31/352;A61K31/353;A61P9/12;A61P25/04;A61P25/06;A61P25/24;A61P25/26;A61P25/28;C07D335/06;C07D405/04;C07D405/12;C07D407/04;C07D409/04;C07D409/06;C07D409/12;C07D413/04;C07D413/06;C07D417/12;(IPC1-7):C07D311/58 主分类号 C07D311/58
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