HISTAMINE H3-RECEPTOR ANTAGONISTS AND THERAPEUTIC USES THEREOF

摘要

The present invention is directed to compounds of the class of piperidyl-imidazole derivative histamine H3-receptor antagonist. Such compounds have affinity for histamine H3-receptor, and preferably penetrate the blood-brain barrier. The compounds can block the soporific effect of an H3-receptor agonist. Illustrative of the compounds of the invention is the molecule 4-(1-cyclohexylvaleroyl-4-piperidyl)-1H-imidazole. These compounds have been found to have utility in treating cognitive disorders and have been found to be useful as appetite suppressants.