摘要 |
A method of inhibiting bone loss comprising administering to a human in need of treatment an effective amount of a compound having the formula <CHEM> wherein R is hydrogen; hydroxy; C1-C6 alkoxy; a group of the formula -O-C(O)-R<a>, wherein R<a> is hydrogen, C1-C6 alkyl optionally substituted with amino, halo, carbonyl, C1-C6 alkoxycarbonyl, C1-C7 alkanoyloxy, carbamoyl and/or aryl; or R<a> is C1-C6 alkenyl optionally substituted with aryl; or R<a> is a C3-C7 cycloalkyl; or R<a> is aryl optionally substituted with hydroxy, C1-C6 alkyl, C1-C6 alkoxy, and/or halo; or R<a> is -O-aryl, said aryl optionally substituted with hydroxy C1-C6 alkyl, C1-C6 alkoxy, and/or halo, or R is a group of the formula -O-SO2-R<b> wherein R<b> may be C1-C6 alkyl or aryl optionally substituted with C1-C6 alkyl; or R is carbamoyloxy wherein the nitrogen may be substituted once or twice with C1-C6 alkyl; or R is a group of the formula -O-C(O)R<c>-O-(C1-C6 alkyl) wherein R<c> is a bond or C1-C6 alkanediyl; R<1> is halo, C1-C6 alkyl, C1-C7 alkyl substituted with C1-C6 alkyl, substituted or unsubstituted C3-C7 cycloalkyl, or substituted or unsubstituted C3-C7 cycloalkenyl; R<2> is O or CH2; R<3> is CH2 or (CH2)2; R<4> is <CHEM> CH2, or a bond; and R<5> is amino, nitrilo optionally substituted once or twice with C1-C6 alkyl; or an N-heterocyclic ring which optionally has another hetero atom selected from N, O, or S in said ring; or a pharmaceutically acceptable salt or solvate thereof. |