发明名称 |
PURIFICATION OF FACTOR IX. |
摘要 |
The present invention relates to a process for purifying Factor IX from an impure protein fraction containing Factor IX. The purification process comprises the steps of adding a solvent and a detergent to an impure protein fraction and incubating the solvent/detergent protein solution to inactivate any viral contaminants. Factor IX is purified from the solvent/detergent protein solution by chromatography on a sulfated polysaccharide resin without first removing the solvent and detergent prior to the purification on the sulfated polysaccharide resin. The Factor IX, purified by the process has a specific activity of at least 85 units/mg. |
申请公布号 |
EP0650364(A1) |
申请公布日期 |
1995.05.03 |
申请号 |
EP19930917167 |
申请日期 |
1993.07.13 |
申请人 |
ALPHA THERAPEUTIC CORPORATION |
发明人 |
HERRING, STEVEN, W. |
分类号 |
A61K38/43;A61P7/02;C07K1/14;C07K1/16;C07K14/745;C12N9/64 |
主分类号 |
A61K38/43 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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