| 摘要 |
The invention relates to a process for the preparation of a benzo[a]quinolizinone derivative of the formula <IMAGE> by reacting a compound of the formula <IMAGE> wherein X is halogen, with carbon monoxide in the presence of a carbonylation catalyst and in the presence of (S)-3-ethoxypyrrolidine or of a lower alkanol or of water; if a lower alkyl ester of 10-chloro-6,7-dihydro-4-oxo-3-phenyl-4H-benzo[a]quinolizine-1-carboxyl ic acid was obtained, converting this to the corresponding free acid; and if 10-chloro-6,7-dihydro-4-oxo-3-phenyl-4H-benzo[a]quinolizine-1-carboxyl ic acid was obtained, reacting this or a reactive derivative thereof with (S)-3-ethoxypyrrolidine in a known manner. |
