发明名称 |
Gamma-pyrone-3-acetic acid as an inhibitor or interleukin-1 beta inventory enzyme |
摘要 |
Novel peptidyl derivatives of formula I are found to be potent inhibitors of interleukin-1 beta converting enzyme (ICE). Compounds of formula I may be useful in the treatment of inflammatory or immune-based diseases of the lung and airways; central nervous system and surrounding membranes; the eyes and ears; joints, bones, and connective tissues; cardiovascular system including the pericardium; the gastrointestinal and urogenital systems; the skin and mucosal membranes. Compounds of formula I are also useful in treating the complications of infection (e.g., gram negative shock) and tumors in which IL 1 functions as an autocrine growth factor or as a mediator of cachexia. <IMAGE>
|
申请公布号 |
US5411985(A) |
申请公布日期 |
1995.05.02 |
申请号 |
US19930062881 |
申请日期 |
1993.05.17 |
申请人 |
MERCK & CO., INC. |
发明人 |
BILLS, GERALD F.;HENSENS, OTTO D.;LIESCH, JERROLD M.;LINGHAM, RUSSEL B.;POLISHOOK, JON D.;SALVATORE, MICHAEL J.;RAGHOOBAR, SUSAN L. |
分类号 |
A61K31/35;C07D309/38;C12P17/06;(IPC1-7):A61K31/35 |
主分类号 |
A61K31/35 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|