| 摘要 |
PURPOSE:To obtain the subject derivative represented by a specified formula, and is useful as an injection preparation for X-ray contrast formation of high safety and usefulness with desirably lowered osmotic pressure and low viscosity because it has excellent contrast properties, sufficiently exhibits the development ability in water-soluble compound. CONSTITUTION:A derivative of formula I {X<1> is Y<1>-NR<1>R<2> [Y<1> is SO2, C=O; R<1>, R<2> are H, a 1-4C alkyl, A-Z (A is an alkylene of 2 or more chain carbon atoms with 2 to 6 total carbon atoms; z is OR<3> (R<3> is SiR<4>R<5>R<6> (R<4> to R<6> each is a 1 to 4C alkyl, phenyl), H, a 1-4C alkyl), NR<7>R<8> (R<7>, R<8> are H, a 1-4C alkyl))], formula II (R<9> is a 1-4C alkyl), Y<2>-AZ [Y<2> is O atom, S(O)n ((n) is 0-2)], NR<1>; X<2>, X<3> are H, X<1>}, for example, tris(2-N,N-bis-ethylsulfamoylpenyl)bis- mucin. The reaction of a compound of formual III [M is MgX' (X' is I, Br, Cl), Li, Na) with a trihalobismuth compound of the formula: BiX3 (X is Cl, Br) gives the objective compound.
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