Compounds, compositions and treatment of allergies and inflammation therewith

摘要

PCT No. PCT/US94/10798 Sec. 371 Date May 27, 1996 Sec. 102(e) Date May 27, 1996 PCT Filed Sep. 23, 1994 PCT Pub. No. WO95/09627 PCT Pub. Date Apr. 13, 1995Novel cyclohexane derivatives of Formula (I) inhibit the production of Tumor Necrosis Factor and are useful in the treatment of disease states mediated or exacerbated by TNF production; they are also useful in the mediation or inhibition of enzymatic or catalytic activity of phosphodiesterase IV and are therefore useful in the treatment of disease states in need of mediation or inhibition thereof.