AMADORI REACTION COMPOUNDS AND PRODUCTS, PROCESS FOR THEIR MANUFACTURE, AND THEIR USE.

摘要

PCT No. PCT/EP93/00327 Sec. 371 Date Oct. 24, 1994 Sec. 102(e) Date Oct. 24, 1994 PCT Filed Feb. 11, 1993 PCT Pub. No. WO93/16087 PCT Pub. Date Aug. 19, 1993Novel Amadori reaction compounds have the formula R1-NH-R2, wherein R1 comprises the D-form of a 1-amino-1-deoxy-2-ketose radical derived from a sugar radical selected from the group of glucose, xylose, galactose, rhamnose, fructose, mannose, 6-deoxyglucose, glucosamine and galactosamine, and R2 comprises the L-form of an aminoacid or peptide radical selected from the group of serine, glycine, proline, histidine, arginine, alanine, aspartic acid, glutamic acid, phenylalanine, treonine, cysteine, cystine, glutamine, asparagine, methionine, tyrosine, hydroxyproline, tryptophane, valine isoleucine, lysine and leucine. Compounds and combinations of compounds having the general formula R1'-NH-R2', wherein R1' comprises a 1-amino-1-deoxy-2-ketose radical derived from the group of simple sugars, oligo- and polysaccharides, and R2' comprises an aminoacid or a peptide radical, are used to produce pharmaceutical preparations which in contact with human leukocytes produce interferon and other cytokines.