HETEROCYCLIC KETONE DERIVATIVES, PREPARATION, INTERMEDIATES AND PHARMACEUTICAL COMPOSITIONS THEREOF

摘要

A compound of the formula: wherein R<1> is H or an optionally substituted hydrocarbon or acyl group; ring A is an optionally further substituted benzene ring; n is an integer of 1 to 10; R<2>, R<3> and R<4> are H or an optionally substituted hydrocarbon group; R<3> and R<4> may form an optionally substituted heterocyclic group, taken together with the adjacent nitrogen atom; k is an integer of 0 to 3; and m is an integer of 1 to 8; provided that when k=0 and m=2, n is an integer of not less than 2 or a pharmaceutically acceptable salt thereof, exhibiting excellent cholinesterase inhibitory activity and monoamine reuptake inhibitory activity, thus being useful as therapeutic/prophylactic medicaments of senile dementia.