| 发明名称 |
L-SELECTIN CLEAVAGE SITE, METHODS OF DIAGNOSIS AND USAGE THEREOF |
| 摘要 |
The present invention discloses the cleavage sequence within L-selectin that becomes cleaved during neutrophil activation/stimulation. A previously unidentified approximately 6 kd L-selectin species, which remains associated with the activated/stimulated neutrophil, is also described. Based on these observation, the present invention provides methods of detecting L-selectin cleavage and methods of reducing the severity of biological responses associated with L-selectin cleavage.
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| 申请公布号 |
CA2134317(A1) |
申请公布日期 |
1995.04.27 |
| 申请号 |
CA19942134317 |
申请日期 |
1994.10.25 |
| 申请人 |
BOEHRINGER, INGELHEIM PHARMACEUTICALS, INC. |
发明人 |
KISHIMOTO, TAKASHI K.;KAHN, JULIUS |
| 分类号 |
C12N15/09;A61K38/00;A61K38/55;A61P29/00;C07K7/08;C07K14/645;C07K14/705;C07K14/81;C07K16/00;C07K16/28;C12N9/48;C12N9/99;C12P21/02;C12Q1/04;C12Q1/37;(IPC1-7):C12N9/50;C07K2/00;C07K14/00;A61K38/02;A61K38/16;C07K16/18;A61K39/395;G01N33/566 |
主分类号 |
C12N15/09 |
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