发明名称 3' THIENYL AND FURYL SUBSTITUTED TAXANE DERIVATIVES; PHARMACEUTICAL COMPOSITIONS THEREOF
摘要 <p>A taxane derivative of the formula <CHEM> wherein R<5> is <CHEM> Z is -OT<5>, T<5> is hydrogen, hydroxyl protecting group, or -COT<6>, T<6> is H, C<5>-C1/4 alkyl, C<5>-C1/4 alkenyl, C<5>-C1/4 alkynyl or monocylic aryl, R<7> is benzoyl, substituted benzoyl or C<5>-C1/4 alkoxycarbonyl, Ac is acetyl, and E<5> and E<6> are independently selected from hydrogen and functional groups which increase the water solubility of the taxane derivative are useful as antitumor agents.</p>
申请公布号 NZ244455(A) 申请公布日期 1995.04.27
申请号 NZ19920244455 申请日期 1992.09.23
申请人 FLORIDA STATE UNIVERSITY 发明人 HOLTON, ROBERT A;BIEDIGER, RONALD J;HOSSAIN NADIZADEH
分类号 A61K31/34;A61K31/341;A61K31/38;A61K31/381;A61P35/00;C07D305/14;C07D407/12;C07D409/12;C07F7/00;C08G67/00;(IPC1-7):C07D407/12 主分类号 A61K31/34
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