摘要 |
<p>To provide a compound excellent in fibrinogen receptor antagonism and cell adhesion factor antagonism. A thiazoline derivative represented by general formula (I) and a salt thereof, wherein R<1> represents cyano, carbamoyl, thiocarbamoyl, morpholinothiocarbonyl, alkylthioimidoyl, -C(=NH)-NR<1><1>R<1><2> (wherein R<1><1> and R<1><2> represent each hydrogen, alkyl, alkoxycarbonyl, cycloalkyl, phenyl, substituted phenyl, aralkyl or substituted aralkyl, or alternatively R<1><1> and R<1><2> may be combined with each other to represent a monovalent heterocyclic group together with the adjacent nitrogen atom) or imidazolin-2-yl; R<2> represents alkyl or aralkyl; R<3> represents carboxy, hydroxy, alkoxycarbonyl, benzyloxycarbonyl or pyridyl-methyloxycarbonyl; and n represents an integer of 1 to 3. <CHEM></p> |
申请人 |
TAISHO PHARMACEUTICAL CO. LTD |
发明人 |
SATO, MASAKAZU, TAISHO PHARMACEUTICAL CO. LTD.;MANAKA, AKIRA, TAISHO PHARMACEUTICAL CO. LTD.;TAKAHASHI, KEIKO, TAISHO PHARMACEUTICAL CO. LTD.;KAWASHIMA, YUTAKA, TAISHO PHARMACEUTICAL CO. LTD.;HATAYAMA, KATSUO, TAISHO PHARMACEUTICAL CO. LTD. |