Process for the synthesis of glycosaminoglycans containing alpha -L-galacturonic acid substituted with nucleophilic groups in position 3

摘要

A process for the synthesis of glycosaminoglycans in which one of the alpha -L-iduronic-2-O-sulfate acid saccharide units, which is characteristic of glycosaminoglycans with heparin or heparan structure, has undergone a structural modification, entirely or in part, with transformation into alpha -L-galacturonic acid substituted in position 3 with nucleophilic groups, is described. The process is carried out by treating glycosaminoglycans having heparin or heparan structure with a nucleophilic reagent in alkaline solution.