发明名称 |
TGF- beta composition for inducing bone growth |
摘要 |
A method is provided for generation of bone at a site of an animal where skeletal tissue is deficient comprising administering to the animal, locally at the bone site in the presence of a source of osteogenic cells, an effective amount of a composition comprising TGF- beta in a pharmaceutically acceptable carrier, provided that such composition excludes a bone morphogenetic cofactor, the composition being administered in an amount effective to induce bone growth at the bone site. Also provided is a device for implantation into a site of an animal where skeletal tissue is deficient comprising a device treated with an effective amount of a composition comprising TGF- beta and a source of osteogenic cells in a pharmaceutically acceptable carrier.
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申请公布号 |
US5409896(A) |
申请公布日期 |
1995.04.25 |
申请号 |
US19930132405 |
申请日期 |
1993.11.12 |
申请人 |
GENENTECH, INC. |
发明人 |
AMMANN, ARTHUR J.;RUDMAN, CHRISTOPHER G. |
分类号 |
A61F2/28;A61F2/30;A61K35/28;A61K38/18;A61L27/22;(IPC1-7):C12N15/00;C07K13/00;A61K37/02 |
主分类号 |
A61F2/28 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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