| 摘要 |
PCT No. PCT/AU92/00485 Sec. 371 Date Jul. 7, 1994 Sec. 102(e) Date Jul. 7, 1994 PCT Filed Sep. 11, 1992 PCT Pub. No. WO93/04713 PCT Pub. Date Mar. 18, 1993.A method and system for the infusion of a drug into a patient involving: (i) calculating a multiplicity of infusion rate profiles for a selected drug by monitoring drug efflux from the body of a group of patients for a corresponding multiplicity of target concentrations of the selected drug; (ii) determining the body size of the patient, such as their Lean Body Mass; (iii) selecting a target concentration of the drug to, in turn, cause selection from the multiplicity of infusion rate profiles of an infusion rate profile substantially corresponding to the infusion rate profile for the selected target concentration; (iv) scaling the selected infusion rate profile by the determined body size or Lean Body Mass of the patient; and (v) administering the drug to the patient in accordance with the scaled profile by means of an infusion device which is controlled to deliver said drug at said scaled infusion rate profile. By using the aforesaid method and system, drugs which are non-linear in their effect on a patient are able to be delivered to the patient in a much more accurate manner thereby avoiding overdosing or underdosing of the drug and the undesirable consequences thereof.
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