发明名称 |
Process for preparing Z and E-rotamers of 3-hydroxy cephem derivatives |
摘要 |
A process for the manufacture of 7-acylamino-3-hydroxycephem-4-carboxylate-1-oxide in E-rotamer form (Formula III), comprises reacting a 7-acylamino-3-exomethylenecepham-4-carboxylate-1-oxide with ozone in an inert organic solvent in the presence of a catalytic amount of an organic or inorganic base at a temperature ranging from about -80 DEG C. to about +20 DEG C. The E-rotamer (wherein the 3-hydroxy group is strongly hydrogen bonded to the carbonyl of the 4-ester group) exhibits different chemical and physical properties from and is more thermodynamically stable than, the Z-rotamer (wherein there is no hydrogen bonding between the 3-hydroxy group and the carbonyl of the 4-ester group).
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申请公布号 |
US5410044(A) |
申请公布日期 |
1995.04.25 |
申请号 |
US19930019269 |
申请日期 |
1993.02.18 |
申请人 |
RANBAXY LABORATORIES, LTD. |
发明人 |
KHANNA, JAG M.;KUMAR, YATENDRA;MALHOTRA, ARUN;ARORA, RAKESH;TIWARI, NEERA |
分类号 |
C07D501/00;C07D501/04;C07D501/59;(IPC1-7):C07D501/04 |
主分类号 |
C07D501/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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