发明名称 |
3,4-dehydropiperidine derivatives |
摘要 |
The invention relates to a group of new 3,4-dehydropiperidine derivatives of the formula <IMAGE> wherein R1 is a hydrogen atom or an alkyl group having 1-3 carbon atoms; Y is a group of the general formula 2 <IMAGE> (2) wherein R2 is a group of the formula -(CH2)n-C(=X)-NR3R4, -(CH2)n-SO2-NR3R4, -(CH2)n-NR5-C(=X)-R6 or -(CH2)n-NR5-SO2-R6, wherein R3, R4 and R5 independent of each other represent hydrogen or alkyl (1-3C), R6 is alkyl (1-3C), X represents O or S; n is 0-4, and R is hydrogen or alkyl (1-3C). These compounds have interesting serotonin-1-like (partial) agonistic activity and can be used for the treatment of migraine.
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申请公布号 |
US5409940(A) |
申请公布日期 |
1995.04.25 |
申请号 |
US19930137753 |
申请日期 |
1993.10.19 |
申请人 |
DUPHAR INTERNATIONAL RESEARCH B.V. |
发明人 |
HULKENBERG, ANTONIUS;VAN CHARLDORP, KARIN J.;VAN HES, ROLF;VAN WIJNGAARDEN, INEKE |
分类号 |
A61K31/435;A61K31/44;A61P25/04;C07D211/70;C07D333/52;C07D409/04;(IPC1-7):C07D409/04 |
主分类号 |
A61K31/435 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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