发明名称 |
HEPATITIS B VIRUS INTERACTS WITH CELLULAR DNA REPAIR PROCESSES |
摘要 |
A method of treating viral disease in an animal or human, comprising the step of interfering with the interaction of the viral protein with a DNA repair complex in the animal or human to be treated. Specific examples include inhibition of the interaction of the X protein from HBV and the XAP-1 protein of the DNA repair complex. The method can also be used for the treatment of cancer secondary to viral infection. Also, there is a nucleic acid sequence encoding the XAP-1 protein and the amino acid sequence of the XAP-1 protein. Antibodies to the protein can be used for diagnostic purposes and the XAP-1 gene can be used as the object of screening assays to detect genetic alterations.
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申请公布号 |
WO9510288(A1) |
申请公布日期 |
1995.04.20 |
申请号 |
WO1994US11451 |
申请日期 |
1994.10.12 |
申请人 |
BAYLOR COLLEGE OF MEDICINE |
发明人 |
BUTEL, JANET, S.;LEE, TEH-HSIU;ELLEDGE, STEPHEN, J. |
分类号 |
A61K31/00;A61K38/00;C07K14/47;C07K16/18;(IPC1-7):A61K31/70;A61K38/17;A61K39/00;A61K39/395;C07H21/04;C07K16/06;C12Q1/00;G01N33/53 |
主分类号 |
A61K31/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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