SELECTIVE ADENOVIRAL MEDIATED GENE TRANSFER INTO VASCULAR NEOINTIMA
摘要
The present invention provides a method of selectively expressing DNA in neointimal cells in an injured blood vessel of a subject comprising administering a replication-deficient recombinant adenovirus which functionally encodes the DNA to the blood vessel at the site of injury, such that the adenovirus remains at the site of injury for a time sufficient for the adenovirus to selectively infect neointimal cells and thereby selectively express the DNA in neointimal cells. In particular, the invention provides administering a replication-deficient recombinant adenovirus which functionally encodes a DNA encoding a protein or an antisense ribonucleic acid. This method can be used to treat restenosis and, relatedly, to prevent neointimal cell proliferation.
申请公布号
WO9510623(A1)
申请公布日期
1995.04.20
申请号
WO1994US11676
申请日期
1994.10.13
申请人
THE GOVERNMENT OF THE UNITED STATES OF AMERICA, RE;FINKEL, TOREN;EPSTEIN, STEPHEN, E.;CRYSTAL, RONALD, G.;GUZMAN, RAUL, J.
发明人
FINKEL, TOREN;EPSTEIN, STEPHEN, E.;CRYSTAL, RONALD, G.;GUZMAN, RAUL, J.