发明名称 |
FAS ANTAGONISTS AND USES THEREOF |
摘要 |
The present invention provides a panel of monoclonal antibodies and binding proteins which specifically bind to human Fas antigen. Some of the antibodies and binding proteins are capable of stimulating T cell proliferation, inhibiting binding of anti-Fas CH-11 monoclonal antibody to cells expressing Fas antigen, blocking anti-Fas CH-11 monoclonal antibody-mediated lysis of cells, and blocking Fas ligand-mediated lysis of cells. The invention also provides for therapeutic compositions comprising the monoclonal antibodies.
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申请公布号 |
WO9510540(A1) |
申请公布日期 |
1995.04.20 |
申请号 |
WO1994US11632 |
申请日期 |
1994.10.13 |
申请人 |
IMMUNEX CORPORATION |
发明人 |
LYNCH, DAVID, H.;ALDERSON, MARK |
分类号 |
C12N15/02;A61K38/00;A61K39/395;A61P37/00;C07K16/18;C07K16/28;C12N15/09;C12P21/02;C12P21/08;C12R1/19;C12R1/91;(IPC1-7):C07K16/28 |
主分类号 |
C12N15/02 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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