| 摘要 |
Compounds of formula (I) which includes pharmaceutically acceptable salts thereof and stereoisomers thereof in which: R1 represents H or one of the following groups (optionally substituted with one or more of halo, cyano, hydroxy or amino): C1-6alkyl, C1-6alkoxy or C1-6alkanoyl; R2 and R3 independently represent H or one of the following groups (optionally substituted with one or more of halo, cyano, hydroxy or amino): C1-6alkyl, C16alkoxy, C1-6alkanoyl, C1-6alkylthio, C1-6alkylsulphinyl or C16alkylsulphonyl; R4 and R5 independently represent H, C1-6alkyl or R4 and R5 combined together with the carbon atom to which they are attached represent C36cycloalkylidene (each alkyl or cycloalkylidene being optionally substituted with one or more of halo, cyano, hydroxy, amino or C1-6alkyl); and R6, R7 and R8 independently represent H, halo, hydroxy, mercapto, cyano or one of the following groups (optionally substituted with one or more of halo, cyano, hydroxy or amino; and any nitrogen atom being optionally substituted with one or more C1-6alkyl): C1-6alkyl, C1-6alkanoyl, C1-6alkoxy, C2-6alkoxycarbonyl, carboxy, C1-6alkanoyloxy, C1-6alkylthio, C1-6alkylsulphinyl, C16alkylsulphonyl, C1-6alkylsulphonylamino, sulphamoyl, carbamoyl, C26alkylcarbamoyl or C1-6alkanoylamino; have utility in the treatment and/or prophylaxis of seizures, neurological disorders such as epilepsy and/or conditions in which there is neurological damage such as stroke, brain trauma, head injuries and haemorrhage. Racemic compounds of formula (I) in which R1, R2, R3, R4 and R8 are H; R5 is methyl, and either: R6 and R7 are both H, or: R6 is 4-chloro and R7 is H or 2-chloro; are known. Processes for the preparation of compounds of formula (I) are also disclosed.
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