Verfahren zur Herstellung von Pregnan-20-on-3beta,5beta,14beta,21-tetrol

摘要

1345042 20 - Ketals of 21 - acyloxy - pregna- 4,14 - diene - 3,20 - diones FARBWERKE HOECHST AG 18 Jan 1971 [28 Jan 1970] 30724/73 Divided out of 1345041 Heading C2U Novel 20 - (ethylenedioxy or 2,2 - dimethylpropylenedioxy) - 21 - acyloxy - pregna - 4,14- dien-3-ones are prepared by reacting 21- hydroxy - pregna - 4,14 - diene - 3,20 - dione or an acylate thereof with ethylene glycol or neopentyl glycol in the presence of an acid, acylating the product (which, when the starting material is a 21-acyloxy steroid, contains at least some 21-ol formed by hydrolysis) and then deketalizing in the 3-position.