发明名称 |
SIGNAL TRANSDUCTION VIA CD28 |
摘要 |
Disclosed are compositions and methods of blocking T cell signal transduction by introducing into a T cell a peptide comprising a PI 3-kinase-binding-sequence which decreases the association of PI 3-kinase with CD28. Also disclosed are compositions and methods of amplifying T cell activation by introducing into a T cell, a plurality of modified T cell surface proteins, the cytoplasmic tail of which comprises a plurality of copies of a PI 3-kinase-binding-sequence. |
申请公布号 |
WO9510628(A2) |
申请公布日期 |
1995.04.20 |
申请号 |
WO1994US10090 |
申请日期 |
1994.09.09 |
申请人 |
DANA-FARBER CANCER INSTITUTE, INC. |
发明人 |
RUDD, CHRISTOPHER, E.;KANTETI, PRASAD |
分类号 |
C07K5/107;C07K14/705;C07K14/725;G01N33/50;(IPC1-7):C12Q/ |
主分类号 |
C07K5/107 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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