Sulfonamide derivatives of benzenefused hydroxy substituted cycloalkyl and heterocyclic ring compounds

摘要

PCT No. PCT/US93/09171 Sec. 371 Date Mar. 31, 1995 Sec. 102(e) Date Mar. 31, 1995 PCT Filed Sep. 30, 1993 PCT Pub. No. WO94/08996 PCT Pub. Date Apr. 28, 1994Compounds of the formula and pharmaceutically acceptable salts and prodrugs thereof, wherein X1, Ar, X, Y1, R1, R2, R3, R5 and n are defined below, which are inhibitors of the production of leukotrienes and/or blockers of leukotriene receptors, methods for preparing said compounds and intermediates useful in the preparation thereof, pharmaceutical compositions thereof methods of treatment therewith. The compounds of the above formula are useful in the prevention or treatment of asthma, arthritis, psoriasis, ulcers, myocardial infarction and related diseases in mammals.