| 发明名称 |
METHODS FOR PRODUCING TRANSGENIC NON-HUMAN ANIMALS HARBORING A YEAST ARTIFICIAL CHROMOSOME. |
| 摘要 |
The present invention provides methods and compositions for transferring large transgene polynucleotides and unlinked selectable marker polynucleotides into eukaryotic cells by a novel method designated co-lipofection. The methods and compositions of the invention are used to produce novel transgenic non-human animals harboring large transgenes, such as a transgene comprising a human APP gene or human immunoglobulin gene. |
| 申请公布号 |
EP0648265(A1) |
申请公布日期 |
1995.04.19 |
| 申请号 |
EP19930915422 |
申请日期 |
1993.06.18 |
| 申请人 |
GENPHARM INTERNATIONAL, INC. |
发明人 |
CHOI, THEODORE;LORING, JEANNE, F.;KAY, ROBERT, M. |
| 分类号 |
A01K67/027;C07K14/47;C07K16/00;C12N5/10;C12N15/09;C12N15/85;C12N15/88;(IPC1-7):C12N15/00;C12N5/00 |
主分类号 |
A01K67/027 |
| 代理机构 |
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代理人 |
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| 主权项 |
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