Phenylalkanolamine derivatives as antagonists of the NMDA receptor.

摘要

Compounds of the formula wherein R is hydrogen, hydroxy, or aryl lower alkyloxy; X is hydrogen; Y is hydroxy or hydrogen; or both X and Y taken together are oxygen; Z is aryl lower alkyl; and m is an integer from 1 to 4 or a diastereomer or an enantiomer thereof, except, the R,R diastereomer of formula I, wherein X is hydrogen, Y is hydroxy, R is benzyloxy, Z is benzyl, and m is 1, or pharmaceutically acceptable salts thereof, reduce adverse effects of toxic injury to central neurons and thus are useful in the treatment of ischemia, stroke, hypoxia and are NMDA receptor antagonists.