| 摘要 |
Method of preparing taxoids of general formula (I) by electrochemical reduction of a taxan derivative of general formula (III). The products of general formula (I) in which R1 is a radical of general formula (II) have remarkable anti-tumor and anti-leukemia properties. In general formulae (I) and (II), R is a hydrogen atom or the radical acetyl, alkoxyacetyl, alkyl or alkylcarbonyl, R1 is a hydrogen atom or a radical of general formula (II) in which Ar is an aryl radical, and R2 is an optionally substituted benzoyl radical, furoyl or thenoyl or an R3-O-CO- radical in which R3 is an alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkynyl, bicycloalkyl, phenyl or heterocyclyl radical. |
