发明名称 |
Method of accessing the risks of developing type I diabetes |
摘要 |
Two subsets of Islet Cell Autoantibodies (ICA), termed restricted and non-restricted, have been identified. The expression of non-restricted ICA correlates with progression to type I diabetes, indicating that these individuals are at much greater risk than are individuals expressing restricted ICA. Differentiation between restricted or non-restricted ICA allows for more accurate prognosis of the development of type I diabetes. Restricted ICA react with beta cells of human and rat islets but not mouse, whereas non-restricted ICA react with humans rat and mouse islets. Restricted ICA can be substantially completely absorbed by incubation with glutamic acid decarboxylase (GAD), whereas non-restricted ICA are partially or not at all absorbed by GAD. Restricted ICA react in a Stiff-Man Syndrome fashion including staining GABAergic neurons in brain sections and western blots of brain extracts, whereas non-restricted ICA does not react with either brain sections nor with GAD antigen in western blots. Restricted ICA contains a higher titer of anti-GAD antibodies than does non-restricted ICA.
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申请公布号 |
US5407802(A) |
申请公布日期 |
1995.04.18 |
申请号 |
US19910814006 |
申请日期 |
1991.12.26 |
申请人 |
IMMULOGIC PHARMACEUTICAL CORPORATION |
发明人 |
EISENBARTH, GEORGE S.;GIANANI, ROBERTO |
分类号 |
G01N33/564;G01N33/573;(IPC1-7):B01N33/567 |
主分类号 |
G01N33/564 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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