| 摘要 |
Novel therapeutic application of perhydroisoindole derivatives of general formula (I), wherein the radicals R are phenyl radicals which can be substituted by a halogen atom or a methyl radical in position 2 or 3; R1 is optionally substituted phenyl, cyclohexadienyl, naphthyl, indenyl, or heterocyclyl which can be substituted; R2 is H, halogen, OH, alkyl, aminoalkyl, alkylaminoalkyl, dialkylaminoalkyl, alkyloxy, alkylthio, acyloxy, carboxy, optionally substituted aklyloxycarbonyl, benzyloxycarbonyl, amino or acylamino; R3 is phenyl which can be substituted in position 2; R4 is OH or fluorine if R5 is H, or R4 and R5 are OH, or R4 and R5 form a bond in their isomer forms. The antiemetic drug produced from the above-mentioned derivatives or optionally their salts, when they exist, can be used for curative and preventive treatments.
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