HYDROXAMIC ACID DERIVATIVES AS INHIBITORS OF CYTOKINE PRODUCTION

摘要

Compounds of formula (I), wherein: R<1> represents hydrogen or a (C1-C6)alkyl, (C1-C6)alkoxycarbonyl(C1-C6)alkyl, phenyl, substituted phenyl, phenyl (C1-C6)alkyl, heterocyclyl, (C1-C6)alkylcarbonyl, phenacyl or substituted phenacyl group; R<2> represents hydrogen or a (C1-C6)alkyl, (C2-C6)alkenyl, phenyl (C1-C6)alkyl, cycloalkyl (C1-C6)alkyl or cycloalkenyl (C1-C6)alkyl group; R<3> represents the characteristic side chain of a natural amino acid which naturally carries a polar amino, hydroxy, mercapto, guanidyl, imidazolyl or indolyl group in the said side chain, in which any such polar group is optionally N-, O- or S-substituted, or R<3> represents the characteristic side chain of a natural amino acid which naturally carries a polar carboxylic acid group in the said side chain, in which such carboxylic acid group is amidated; R<4> represents hydrogen or a (C1-C6)alkyl or phenyl(C1-C6)alkyl group; R<5> represents hydrogen or a methyl group; n is 0, 1 or 2; and A represents a (C1-C6)hydrocarbon chain optionally substituted with one or more (C1-C6)alkyl, phenyl, or substituted phenyl groups; or salts, solvates or hydrates thereof are inhibitors of TNF production and matrix metalloproteinase inhibitors.