Carbostyril derivatives as phosphodiesterase inhibitors.

摘要

A pharmaceutical preparation comprising at least one compound selected from the group consisting of carbostyril derivatives having the general formula: wherein R<1> is hydrogen or a lower alkyl group optionally having hydroxy group as a substituent; R<2> is a phenyl(lower alkyl) group optionally having 1 to 3 substituents selected from the group consisting of a lower alkoxy group and a halogen atom on the phenyl ring, pyridyl(lower alkyl) group, or a group of the formula -A-NR<3>R<4> (wherein A is a lower alkylene group, R<3> and R<4> are the same or different and represent a lower alkyl group or phenyl group), and a salt thereof, which is useful as an agent for treating thrombosis, more particularly, as an agent for inhibiting platelet aggregation, an agent for platelet aggregate dissociation, an ameliorant of cerebral circulation and a phosphodiesterase inhibitor.