| 摘要 |
<p>Cytotoxic compounds isolated and purified from a marine cyanobacterium Lyngbya majuscula are disclosed. The specific compounds are termed 'Curacin A', 'Curacin B', and 'Curacin C' along with semi-synthetic isomers and variants termed 'Curacin D' and '15,16-dihydrocuracin A'. The compounds exhibit substantial biological activity against proliferating cells, and appear to be antimitotics. Methods for using the compounds are also disclosed. The active portions of these molecules appear to comprise at least the thiazoline ring and two alkyl groups appended to separate portions of the ring, including a short (C1 - C6) alkyl group, with or without rings or double bonds, and a long (C8 - C22) alkyl group, with or without double bonds or other lipophilic moieties.</p> |
