发明名称 |
AZLACTONE-FUNCTIONAL SUBSTRATES, CORNEAL PROSTHESES, AND MANUFACTURE AND USE THEREOF. |
摘要 |
Azlactone-functional substrates, (especially hydrogels), mammalian body implants, and methods of making and using them are disclosed. The azlactone-functional substrates are the reaction product of substrates having azlactone-reactive nucleophilic surfaces and a multi-functional azlactone composition having at least two azlactone moieties, where at least one moiety covalently couples to the azlactone-reactive nucleophilic surface and at least one moiety remains available for further nucleophilic reaction, such as with a biologically active material. A preferred use of azlactone-functional hydrogel is as the optical element of a corneal prosthesis which enhances epithethial cell growth. |
申请公布号 |
EP0647143(A1) |
申请公布日期 |
1995.04.12 |
申请号 |
EP19930913870 |
申请日期 |
1993.05.13 |
申请人 |
MINNESOTA MINING AND MANUFACTURING COMPANY |
发明人 |
CAPECCHI, JOHN, T.;HEILMANN, STEVEN, M.;KREPSKI, LARRY, R.;KWON, OH-SEUNG;OLSON, DAVID, B. |
分类号 |
A61L27/00;A61L27/28;A61L27/34;A61L27/50;C07C45/71;C07C49/84;C08F8/30 |
主分类号 |
A61L27/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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