NEW NON IONIC IODINE-CONTAINING DIMERS USEFUL AS X-RAY CONTRAST AGENTS, METHOD FOR THE PREPARATION THEREOF, AND GALENICAL COMPOSITIONS CONTAINING THEM.

摘要

The invention relates to new-ionic iodine-containing X-ray contrast agents, having a dimer structure and general formula (I), where the union bridge is N-substituted azapentanodiamide, wherein R1 and R7, similar or different, are a linear or branched C2-C4 polyhydroxyalkyl radical having from 1 to 3 OH groups; R2 and R6, similar or different, are hydrogen, methyl or 2- hydroxyethyl; R3 and R5, similar or different, are hydrogen or methyl; R4 is hydrogen, methyl, methoxymethyl or a linear or branched C2-C4 polyhydroxyalkyl radical having from 1 to 3 OH groups. The invention also refers to methods for the preparation of products having formula (I) as well as to pharmaceutical preparations which contain said products. <CHEM>